3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-N-methoxy-N,4-dimethylbenzamide

Base Information

Chemical Name:3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-N-methoxy-N,4-dimethylbenzamide
CAS No.:1380281-60-6
Molecular Formula:C₂₁H₁₉F₂N₃O₂
Molecular Weight:383.398
Hs Code.:

Synonyms:3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-N-methoxy-N,4-dimethylbenzamide

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Chemical Property of 3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-N-methoxy-N,4-dimethylbenzamide

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Technology Process of 3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-N-methoxy-N,4-dimethylbenzamide

There total 4 articles about 3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-N-methoxy-N,4-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1380281-59-3
3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylbenzoic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1380281-60-6
3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-N-methoxy-N,4-dimethylbenzamide

Guidance literature:: 3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylbenzoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In tetrahydrofuran; at 20 ℃; for 0.5h;

N,O-dimethylhydroxylamine*hydrochloride; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 144025-03-6
2,4-difluorophenylboronic acid

: 1380281-60-6
3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-N-methoxy-N,4-dimethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 2.5 h / 75 °C

2.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

3.1: sodium hydroxide; methanol / tetrahydrofuran / 18 h / 20 °C

4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / tetrahydrofuran / 0.5 h / 20 °C

4.2: 18 h / 20 °C

With 4-methyl-morpholine; methanol; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; ethanol; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1380281-57-1
2-bromo-6-(2,4-difluorophenyl)pyridine

: 1380281-60-6
3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-N-methoxy-N,4-dimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

2.1: sodium hydroxide; methanol / tetrahydrofuran / 18 h / 20 °C

3.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / tetrahydrofuran / 0.5 h / 20 °C

3.2: 18 h / 20 °C

With 4-methyl-morpholine; methanol; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; palladium diacetate; In tetrahydrofuran; toluene;