2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol

Base Information

Chemical Name:2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol
CAS No.:1380281-63-9
Molecular Formula:C₂₅H₂₂F₂N₄O
Molecular Weight:432.473
Hs Code.:

Synonyms:2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol

Suppliers and Price of 2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol

There total 14 articles about 2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1380281-57-1
2-bromo-6-(2,4-difluorophenyl)pyridine

: 1380281-56-0
2-[4-(3-amino-4-methylphenyl)pyrimidin-2-yl]propan-2-ol

: 1380281-63-9
2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol

Guidance literature:: With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene; at 85 ℃; for 18h;

Reference yield:

: 1380281-62-8
(E)-1-(3-((6-(2,4-difluorophenyl)pyridin-2-yl)amino)-4-methylphenyl)-3-(dimethylamino)prop-2-en-1-one

: 2-hydroxy-2-methylpropanimidamide hydrochloride

: 1380281-63-9
2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 18h;

Reference yield:

: 144025-03-6
2,4-difluorophenylboronic acid

: 1380281-63-9
2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 2.5 h / 75 °C

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

With sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In ethanol; water; toluene; 1: Suzuki Coupling;