(2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanol

Base Information

• Chemical Name: (2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanol
• CAS No.: 136866-37-0
• Molecular Formula: C₁₄H₁₆N₂O₄
• Molecular Weight: 276.292
• Mol file: 136866-37-0.mol

Synonyms:(2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanol

Chemical Property of (2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanol

Chemical Property:

Purity/Quality:

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Technology Process of (2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanol

There total 1 articles about (2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dimethoxypyrazine (4774-15-6) + ortho-anisaldehyde (135-02-4) → (2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanol (136866-37-0)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; Yield given. Multistep reaction; 1.) THF, 0 deg C, 45 min, 2.) THF, 0 deg C, 2 h;

DOI:10.1016/0022-328X(91)86074-Z

Reference yield: 77.0%

(2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanol (136866-37-0) → (2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanone (136866-42-7)

Guidance literature:

With manganese(IV) oxide; In toluene; for 1h; Heating;

DOI:10.1016/0022-328X(91)86074-Z

upstream raw materials:

2,6-dimethoxypyrazine

ortho-anisaldehyde

Downstream raw materials:

(2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanone

Refernces