2,6-Dimethoxypyrazine

Base Information

• Chemical Name: 2,6-Dimethoxypyrazine
• CAS No.: 4774-15-6
• Molecular Formula: C6H8N2O2
• Molecular Weight: 140.14
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30390805
• Nikkaji Number: J385.363B
• Wikidata: Q72468463
• Mol file: 4774-15-6.mol

Synonyms:2,6-dimethoxypyrazine;4774-15-6;MFCD00955843;dimethoxypyrazine;2 pound not6-dimethoxypyrazine;SCHEMBL3063023;DTXSID30390805;BCP32233;AKOS006273994;CS-W005486;AS-17333;SY031635;A7297;FT-0655334;EN300-133250;F11651;J-507497;F2147-1827

Chemical Property of 2,6-Dimethoxypyrazine

Chemical Property:

• Vapor Pressure: 0.984mmHg at 25°C
• Melting Point: 31-31.5 °C
• Refractive Index: 1.49
• Boiling Point: 184.849 °C at 760 mmHg
• PKA: 0.15±0.10(Predicted)
• Flash Point: 65.718 °C
• PSA: 44.24000
• Density: 1.131 g/cm³
• LogP: 0.49380
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 140.058577502
• Heavy Atom Count: 10
• Complexity: 89.7

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dimethoxypyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CN=CC(=N1)OC

Technology Process of 2,6-Dimethoxypyrazine

There total 4 articles about 2,6-Dimethoxypyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-dichloropyrazine (4774-14-5) + sodium methylate (124-41-4) → 2,6-dimethoxypyrazine (4774-15-6)

Guidance literature:

In methanol; for 18h; Reflux;

DOI:10.1016/j.tet.2009.07.065

Reference yield: 66.0%

2,6-dichloropyrazine (4774-14-5) + sodium methylate (124-41-4) → 2,6-dimethoxypyrazine (4774-15-6) + 2-chloro-6-methoxypyrazine (33332-30-8)

Guidance literature:

In methanol; for 3.5h; Reflux;

DOI:10.1016/j.tet.2009.07.065

Reference yield:

2,6-dibromopyrazine (23229-25-6) + sodium methylate (124-41-4) → 2,6-dimethoxypyrazine (4774-15-6)

Guidance literature:

DOI:10.1021/ja01174a041

upstream raw materials:

2,6-dibromopyrazine

sodium methylate

2,6-dichloropyrazine

Downstream raw materials:

(2,6-dimethoxy-3-pyrazinyl)phenylmethanone

(2,6-dimethoxy-3-pyrazinyl)-2'-methoxyphenyl methanol

2,6-dimethoxy-3-pyrazinecarboxaldehyde

(3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2-(3,5-dimethoxy-pyrazin-2-yl)-tetrahydro-furan-2-ol