3-tert-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid

Base Information

Chemical Name:3-tert-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid
CAS No.:843673-37-0
Molecular Formula:C₅₁H₇₀ClNO₁₅Si
Molecular Weight:1000.65
Hs Code.:

3-<i>tert</i>-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid

Synonyms:3-tert-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid

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Chemical Property of 3-tert-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid

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Technology Process of 3-tert-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid

There total 7 articles about 3-tert-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 843673-36-9
C₅₇H₈₂ClNO₁₆Si₂

: 843673-37-0
3-tert-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1002/anie.200461428

Reference yield:

: 994-30-9
triethylsilyl chloride

: 843673-37-0
3-tert-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / imidazole / dimethylformamide / 20 °C

2: 87 percent / LiN(TMS)2 / tetrahydrofuran / -78 °C

3: 80 percent / Pd(PPh₃)4; CuI; EtN(i-Pr)2 / dimethylformamide / 20 °C

4: 90 percent / aq. KOH / tetrahydrofuran; methanol

With 1H-imidazole; potassium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 3: Sonogashira coupling;
DOI:10.1002/anie.200461428

Reference yield:

: 3-tert-butoxycarbonylamino-3-(3-chloro-4-hydroxy-5-methoxymethoxy-phenyl)-propionic acid methyl ester

: 843673-37-0
3-tert-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / CsF / dimethylformamide / 75 °C

2: 98 percent / imidazole / dimethylformamide / 20 °C

3: 87 percent / LiN(TMS)2 / tetrahydrofuran / -78 °C

4: 80 percent / Pd(PPh₃)4; CuI; EtN(i-Pr)2 / dimethylformamide / 20 °C

5: 90 percent / aq. KOH / tetrahydrofuran; methanol

With 1H-imidazole; potassium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; cesium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 4: Sonogashira coupling;
DOI:10.1002/anie.200461428