5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxylic acid

Base Information

Chemical Name:5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxylic acid
CAS No.:1393119-42-0
Molecular Formula:C₁₆H₁₀Cl₂F₃NO₃S
Molecular Weight:424.228
Hs Code.:

Synonyms:5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxylic acid

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Chemical Property of 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxylic acid

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Technology Process of 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxylic acid

There total 6 articles about 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393119-41-9
5-{5-(3,5-dichlorophenyl)-5-(trrfluoromethyl)-4,5-dihydroisoxazol-3-yl}-2-methylthiophene-3-carbonitrile

: 1393119-42-0
5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxylic acid

Guidance literature:: 5-{5-(3,5-dichlorophenyl)-5-(trrfluoromethyl)-4,5-dihydroisoxazol-3-yl}-2-methylthiophene-3-carbonitrile; With water; potassium hydroxide; In ethylene glycol; at 100 ℃; for 1h; Microwave irradiation; Sealed tube;

With hydrogenchloride; In water; ethylene glycol; at 20 ℃;

Reference yield:

: 1393119-39-5
1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one

: 1393119-42-0
5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 18 h / 0 - 20 °C

2.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 18 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation; Sealed tube

4.1: potassium hydroxide; water / ethylene glycol / 1 h / 100 °C / Microwave irradiation; Sealed tube

4.2: 20 °C

With hydroxylamine hydrochloride; water; triethylamine; trifluoroacetic anhydride; potassium hydroxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;

Reference yield:

: 13679-74-8
2-Acetyl-5-methylthiophen

: 1393119-42-0
5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium acetate; bromine / water / 18 h / 20 °C

2.1: lithium hydride / tetrahydrofuran / 5 h / 60 °C

3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 18 h / 0 - 20 °C

4.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 18 h / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation; Sealed tube

6.1: potassium hydroxide; water / ethylene glycol / 1 h / 100 °C / Microwave irradiation; Sealed tube

6.2: 20 °C

With hydroxylamine hydrochloride; water; bromine; sodium acetate; lithium hydride; triethylamine; trifluoroacetic anhydride; potassium hydroxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide;