1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one

Base Information

Chemical Name:1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one
CAS No.:1393119-39-5
Molecular Formula:C₁₅H₁₀BrCl₂F₃O₂S
Molecular Weight:462.114
Hs Code.:

Synonyms:1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one

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Chemical Property of 1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one

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Technology Process of 1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one

There total 1 articles about 1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36901-17-4
1-(4-bromo-5-methylthiophen-2-yl)ethan-1-one

: 130336-16-2
3,5-dichloro-2,2,2-trifluoroacetophenone

: 1393119-39-5
1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one

Guidance literature:: With lithium hydride; In tetrahydrofuran; at 60 ℃; for 5h;

Reference yield:

: 1393119-39-5
1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one

: 1393119-40-8
(E/Z)-1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one

Guidance literature:: With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield:

: 1393119-39-5
1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one

: C₁₆H₉Cl₃F₃NO₂S

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 18 h / 0 - 20 °C

2.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 18 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation; Sealed tube

4.1: potassium hydroxide; water / ethylene glycol / 1 h / 100 °C / Microwave irradiation; Sealed tube

4.2: 20 °C

5.1: thionyl chloride / toluene / 0.5 h / Reflux

With thionyl chloride; hydroxylamine hydrochloride; water; triethylamine; trifluoroacetic anhydride; potassium hydroxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; toluene;