N-(2-((cyanomethyl)amino)-2-oxoethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxamide

Base Information

Chemical Name:N-(2-((cyanomethyl)amino)-2-oxoethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxamide
CAS No.:1393119-12-4
Molecular Formula:C₂₀H₁₅Cl₂F₃N₄O₃S
Molecular Weight:519.331
Hs Code.:

Synonyms:N-(2-((cyanomethyl)amino)-2-oxoethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxamide

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Chemical Property of N-(2-((cyanomethyl)amino)-2-oxoethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxamide

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Technology Process of N-(2-((cyanomethyl)amino)-2-oxoethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxamide

There total 8 articles about N-(2-((cyanomethyl)amino)-2-oxoethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₉Cl₃F₃NO₂S

: 117087-84-0
Gly-NHCH₂CN*MeSO₃H

: 1393119-12-4
N-(2-((cyanomethyl)amino)-2-oxoethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1393119-45-3
3-(4-bromo-5-methylthiophen-2-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

: 1393119-12-4
N-(2-((cyanomethyl)amino)-2-oxoethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation; Sealed tube

2.1: potassium hydroxide; water / ethylene glycol / 1 h / 100 °C / Microwave irradiation; Sealed tube

2.2: 20 °C

3.1: thionyl chloride / toluene / 0.5 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

With thionyl chloride; water; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; ethylene glycol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 36901-17-4
1-(4-bromo-5-methylthiophen-2-yl)ethan-1-one

: 1393119-12-4
N-(2-((cyanomethyl)amino)-2-oxoethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylthiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydride / tetrahydrofuran / 5 h / 60 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 18 h / 0 - 20 °C

3.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 18 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation; Sealed tube

5.1: potassium hydroxide; water / ethylene glycol / 1 h / 100 °C / Microwave irradiation; Sealed tube

5.2: 20 °C

6.1: thionyl chloride / toluene / 0.5 h / Reflux

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

With thionyl chloride; hydroxylamine hydrochloride; water; lithium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; potassium hydroxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; toluene;