2,2'-((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))diacetonitrile

Base Information

Chemical Name:2,2'-((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))diacetonitrile
CAS No.:1453106-64-3
Molecular Formula:C₂₃H₂₀N₄O₂
Molecular Weight:384.437
Hs Code.:

Synonyms:2,2'-((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))diacetonitrile

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Chemical Property of 2,2'-((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))diacetonitrile

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Technology Process of 2,2'-((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))diacetonitrile

There total 4 articles about 2,2'-((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))diacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1453106-62-1
bis((4R,5S)-4-(bromomethyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

: 1453106-64-3
2,2'-((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))diacetonitrile

Guidance literature:: With sodium cyanide; In dimethyl sulfoxide; at 50 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1002/ejoc.201300279

Reference yield:

: 133463-87-3
(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

: 1453106-64-3
2,2'-((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))diacetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 20 °C / Inert atmosphere; Schlenk technique

2: sodium cyanide / dimethyl sulfoxide / 12 h / 50 °C / Inert atmosphere; Schlenk technique

With sodium cyanide; carbon tetrabromide; triphenylphosphine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/ejoc.201300279

Reference yield:

: 10344-69-1
diethyl malonoimidate dihydrochloride

: 1453106-64-3
2,2'-((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))diacetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 18 h / Inert atmosphere; Schlenk technique; Reflux

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 20 °C / Inert atmosphere; Schlenk technique

3: sodium cyanide / dimethyl sulfoxide / 12 h / 50 °C / Inert atmosphere; Schlenk technique

With sodium cyanide; carbon tetrabromide; triphenylphosphine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/ejoc.201300279