<1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(S)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester

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Chemical Name:<1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(S)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester
CAS No.:113116-81-7
Molecular Formula:C₂₅H₂₈N₄O₆
Molecular Weight:480.521
Hs Code.:

Synonyms:<1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(S)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester

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Chemical Property of <1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(S)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester

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Technology Process of <1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(S)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester

There total 2 articles about <1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(S)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 123486-12-4
2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid 5-(1-methylethyl) 1-(4-nitrophenyl) diester

: 113094-77-2
<1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(R)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester

: 113116-81-7
<1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(S)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester

Guidance literature:: In ethyl acetate; for 16h; Ambient temperature;
DOI:10.1021/jm00171a044

Reference yield:

: 108931-52-8
1,4-Dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,1-methylethyl ester

: 113116-81-7
<1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(S)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaHCO₃ / CH₂Cl₂; H₂O / 16 h / Ambient temperature

2: 47 percent / ethyl acetate / 16 h / Ambient temperature

With sodium hydrogencarbonate; In dichloromethane; water; ethyl acetate;
DOI:10.1021/jm00171a044