(S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

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Chemical Name:(S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate
CAS No.:1632323-15-9
Molecular Formula:C₂₈H₃₉N₃O₄
Molecular Weight:481.635
Hs Code.:

Synonyms:(S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

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Chemical Property of (S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

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Technology Process of (S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

There total 5 articles about (S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 517-22-6
2,4-dimethyl-3-ethyl-pyrrole

: 1632323-13-7
(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

: 1632323-15-9
(S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

: 1632323-14-8
methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Guidance literature:: 2,4-dimethyl-3-ethyl-pyrrole; With aluminum (III) chloride; In dichloromethane; at 25 ℃; Inert atmosphere;

(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate; In dichloromethane; at 25 ℃; Overall yield = 72 %; Overall yield = 149 mg; Optical yield = 75 %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1341275

Reference yield:

: 1632324-67-4
C₈H₁₃AlCl₃N

: 1632323-13-7
(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

: 1632323-15-9
(S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

: 1632323-14-8
methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Guidance literature:: In dichloromethane; at 25 ℃; Optical yield = 75 %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1341275

Reference yield:

: 1632323-27-3
C₂₂H₃₀N₂O₄

: 1632323-15-9
(S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

: 1632323-14-8
methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: allyl-trimethyl-silane; Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 25 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 25 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

With aluminum (III) chloride; Hoveyda-Grubbs catalyst second generation; allyl-trimethyl-silane; In dichloromethane; 2.1: |Friedel-Crafts Alkylation / 2.2: |Friedel-Crafts Alkylation;
DOI:10.1055/s-0033-1341275