(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

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Chemical Name:(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate
CAS No.:1632323-13-7
Molecular Formula:C₂₀H₂₆N₂O₄
Molecular Weight:358.437
Hs Code.:

Synonyms:(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

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Chemical Property of (S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

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Technology Process of (S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

There total 2 articles about (S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1632323-27-3
C₂₂H₃₀N₂O₄

: 1632323-13-7
(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

Guidance literature:: With Hoveyda-Grubbs catalyst second generation; allyl-trimethyl-silane; In dichloromethane; at 25 ℃; for 4h; Inert atmosphere;
DOI:10.1055/s-0033-1341275

Reference yield:

: (S)-2-((S)-2-Allylamino-3-phenyl-propionylamino)-4-methyl-pentanoic acid methyl ester

: 1632323-13-7
(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -10 °C / Inert atmosphere

2: allyl-trimethyl-silane; Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 25 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; N-ethyl-N,N-diisopropylamine; allyl-trimethyl-silane; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0033-1341275

Reference yield:

: 517-22-6
2,4-dimethyl-3-ethyl-pyrrole

: 1632323-13-7
(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

: 1632323-15-9
(S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

: 1632323-14-8
methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Guidance literature:: 2,4-dimethyl-3-ethyl-pyrrole; With aluminum (III) chloride; In dichloromethane; at 25 ℃; Inert atmosphere;

(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate; In dichloromethane; at 25 ℃; Overall yield = 72 %; Overall yield = 149 mg; Optical yield = 75 %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1341275