methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Base Information

Chemical Name:methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate
CAS No.:1632323-14-8
Molecular Formula:C₂₈H₃₉N₃O₄
Molecular Weight:481.635
Hs Code.:

Synonyms:methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Suppliers and Price of methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

There total 5 articles about methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 517-22-6
2,4-dimethyl-3-ethyl-pyrrole

: 1632323-13-7
(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

: 1632323-15-9
(S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

: 1632323-14-8
methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Guidance literature:: 2,4-dimethyl-3-ethyl-pyrrole; With aluminum (III) chloride; In dichloromethane; at 25 ℃; Inert atmosphere;

(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate; In dichloromethane; at 25 ℃; Overall yield = 72 %; Overall yield = 149 mg; Optical yield = 75 %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1341275

Reference yield:

: 1632324-67-4
C₈H₁₃AlCl₃N

: 1632323-13-7
(S)-methyl 4-methyl-2-((S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanamido)pentanoate

: 1632323-15-9
(S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

: 1632323-14-8
methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Guidance literature:: In dichloromethane; at 25 ℃; Optical yield = 75 %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1341275

Reference yield:

: 1632323-27-3
C₂₂H₃₀N₂O₄

: 1632323-15-9
(S)-methyl 2-((S)-2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

: 1632323-14-8
methyl 2-(2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: allyl-trimethyl-silane; Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 25 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 25 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

With aluminum (III) chloride; Hoveyda-Grubbs catalyst second generation; allyl-trimethyl-silane; In dichloromethane; 2.1: |Friedel-Crafts Alkylation / 2.2: |Friedel-Crafts Alkylation;
DOI:10.1055/s-0033-1341275