(E)-5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-4-hydroxyphenyl)diazenyl)benzoic acid trifluoroacetic salt

Base Information

• Chemical Name: (E)-5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-4-hydroxyphenyl)diazenyl)benzoic acid trifluoroacetic salt
• CAS No.: 1474020-00-2
• Molecular Formula: C₂HF₃O₂*C₃₆H₄₃N₉O₉
• Molecular Weight: 859.816
• Mol file: 1474020-00-2.mol

Synonyms:(E)-5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-4-hydroxyphenyl)diazenyl)benzoic acid trifluoroacetic salt

Chemical Property of (E)-5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-4-hydroxyphenyl)diazenyl)benzoic acid trifluoroacetic salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-4-hydroxyphenyl)diazenyl)benzoic acid trifluoroacetic salt

There total 9 articles about (E)-5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-4-hydroxyphenyl)diazenyl)benzoic acid trifluoroacetic salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(E)-5-(aminomethyl)-2-((2-((2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-yl)oxy)-4-hydroxyphenyl)diazenyl)benzoic acid (1474019-95-8) + trifluoroacetic acid (76-05-1) → (E)-5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-4-hydroxyphenyl)diazenyl)benzoic acid trifluoroacetic salt (1474020-00-2)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201304096

Reference yield:

(E)-methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-((2-((2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-yl)oxy)-4-hydroxyphenyl)diazenyl)benzoate (1474019-91-4) → (E)-5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-4-hydroxyphenyl)diazenyl)benzoic acid trifluoroacetic salt (1474020-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: lithium hydroxide; water / methanol / 16 h / 20 °C / Inert atmosphere

3: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With piperidine; water; lithium hydroxide; In methanol; dichloromethane;

DOI:10.1002/anie.201304096

Reference yield:

methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate (1474019-88-9) → (E)-5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-4-hydroxyphenyl)diazenyl)benzoic acid trifluoroacetic salt (1474020-00-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 1 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: piperidine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3.1: lithium hydroxide; water / methanol / 16 h / 20 °C / Inert atmosphere

4.1: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With piperidine; hydrogenchloride; water; lithium hydroxide; sodium nitrite; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1002/anie.201304096

upstream raw materials:

methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate

(E)-methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-((2-((2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-yl)oxy)-4-hydroxyphenyl)diazenyl)benzoate

(E)-5-(aminomethyl)-2-((2-((2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-yl)oxy)-4-hydroxyphenyl)diazenyl)benzoic acid

trifluoroacetic acid

Downstream raw materials:

5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid

C₂₂H₂₃N₇O₄