methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate

Base Information

Chemical Name:methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate
CAS No.:1474019-88-9
Molecular Formula:C₂₄H₂₂N₂O₄
Molecular Weight:402.45
Hs Code.:

Synonyms:methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate

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Chemical Property of methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate

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Technology Process of methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate

There total 2 articles about methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 159847-81-1
methyl 2-AMINO-5-CYANOBENZOATE

: 1474019-88-9
methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5h; Inert atmosphere;
DOI:10.1002/anie.201304096

Reference yield:

: 52727-57-8
5-bromo-2-aminobenzoic acid methyl ester

: 1474019-88-9
methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-methyl-pyrrolidin-2-one / 5 h / Inert atmosphere; Reflux

1.2: 1 h / 20 - 60 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 0 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1002/anie.201304096

Reference yield: 75.0%

: 1246999-34-7
tert-butyl (2-(2-(2-(2-(3-hydroxyphenoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate

: 1474019-88-9
methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate

: 1474019-91-4
(E)-methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-((2-((2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-yl)oxy)-4-hydroxyphenyl)diazenyl)benzoate

Guidance literature:: methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate; With hydrogenchloride; sodium nitrite; In water; acetonitrile; at 0 ℃; for 1h; Inert atmosphere;

tert-butyl (2-(2-(2-(2-(3-hydroxyphenoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate; With sodium carbonate; sodium hydroxide; In water; acetonitrile; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/anie.201304096