5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid

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Chemical Name:5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid
CAS No.:1474020-03-5
Molecular Formula:C₄₆H₅₇N₁₁O₁₁S
Molecular Weight:972.092
Hs Code.:

5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid

Synonyms:5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid

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Chemical Property of 5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid

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Technology Process of 5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid

There total 11 articles about 5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1474020-00-2
(E)-5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-4-hydroxyphenyl)diazenyl)benzoic acid trifluoroacetic salt

: 35013-72-0
biotin N-Hydroxysuccinimide ester

: 1474020-03-5
5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201304096

Reference yield:

: 1474019-91-4
(E)-methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-((2-((2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-yl)oxy)-4-hydroxyphenyl)diazenyl)benzoate

: 1474020-03-5
5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: lithium hydroxide; water / methanol / 16 h / 20 °C / Inert atmosphere

3: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dimethyl sulfoxide / 2 h / 20 °C / Inert atmosphere

With piperidine; water; triethylamine; lithium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/anie.201304096

Reference yield:

: 1474019-88-9
methyl 5-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)-2-aminobenzoate

: 1474020-03-5
5-((5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)methyl)-2-((E)-(4-hydroxy-2-((13-oxo-17-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)phenyl)diazenyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 1 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: piperidine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3.1: lithium hydroxide; water / methanol / 16 h / 20 °C / Inert atmosphere

4.1: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / dimethyl sulfoxide / 2 h / 20 °C / Inert atmosphere

With piperidine; hydrogenchloride; water; triethylamine; lithium hydroxide; sodium nitrite; In methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/anie.201304096