2-Amino-6-methyl-4,6-diphenyl-1,3-cyclohexadiencarbonitril

Base Information

• Chemical Name: 2-Amino-6-methyl-4,6-diphenyl-1,3-cyclohexadiencarbonitril
• CAS No.: 58245-33-3
• Molecular Formula: C₂₀H₁₈N₂
• Molecular Weight: 286.376
• Mol file: 58245-33-3.mol

Synonyms:2-Amino-6-methyl-4,6-diphenyl-1,3-cyclohexadiencarbonitril

Chemical Property of 2-Amino-6-methyl-4,6-diphenyl-1,3-cyclohexadiencarbonitril

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-6-methyl-4,6-diphenyl-1,3-cyclohexadiencarbonitril

There total 4 articles about 2-Amino-6-methyl-4,6-diphenyl-1,3-cyclohexadiencarbonitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

diethyl 1-cyanomethylphosphonate (2537-48-6) + acetophenone (98-86-2) → 2-Amino-6-methyl-4,6-diphenyl-1,3-cyclohexadiencarbonitril (58245-33-3)

Guidance literature:

sodium hydride; In tetrahydrofuran; at 20 ℃; for 96h;

DOI:10.1016/j.bmcl.2007.10.048

Reference yield: 18.0%

(E)-3-phenyl-2-butenenitrile (14368-40-2,14799-79-2,14799-78-1) → 2-Amino-6-methyl-4,6-diphenyl-1,3-cyclohexadiencarbonitril (58245-33-3)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -20 - 20 ℃;

DOI:10.1016/j.bmcl.2007.10.048

Reference yield:

Aethyl-2,4-diphenyl-5-cyano-5-aethoxycarbonyl-6-imino-4-methyl-1-cyclohexencarboxylat (58245-30-0) → 2-Amino-6-methyl-4,6-diphenyl-1,3-cyclohexadiencarbonitril (58245-33-3)

Guidance literature:

With potassium hydroxide; In ethylene glycol;

DOI:10.1246/bcsj.48.3317

upstream raw materials:

2-methyl-2-phenyl-succinonitrile

Aethyl-2,4-diphenyl-5-cyano-5-aethoxycarbonyl-6-imino-4-methyl-1-cyclohexencarboxylat

diethyl 1-cyanomethylphosphonate

acetophenone

Downstream raw materials:

C₂₁H₁₉N₃