methyl (1R,2R)-2-aminocyclohexylcarbamate hydrochloride

Base Information

• Chemical Name: methyl (1R,2R)-2-aminocyclohexylcarbamate hydrochloride
• CAS No.: 1257517-07-9
• Molecular Formula: C₈H₁₆N₂O₂*ClH
• Molecular Weight: 208.688
• Mol file: 1257517-07-9.mol

Synonyms:methyl (1R,2R)-2-aminocyclohexylcarbamate hydrochloride

Chemical Property of methyl (1R,2R)-2-aminocyclohexylcarbamate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (1R,2R)-2-aminocyclohexylcarbamate hydrochloride

There total 2 articles about methyl (1R,2R)-2-aminocyclohexylcarbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + (3aR,7aR)-1,3,3a,4,5,6,7,7a-octahydrobenzimidazol-2-one (1257216-04-8) → methyl (1R,2R)-2-aminocyclohexylcarbamate hydrochloride (1257517-07-9)

Guidance literature:

With thionyl chloride; at 60 - 70 ℃; for 1h;

DOI:10.1021/jo101723v

Reference yield:

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) → methyl (1R,2R)-2-aminocyclohexylcarbamate hydrochloride (1257517-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: isopropyl alcohol / Reflux

2: thionyl chloride / Reflux

With thionyl chloride; In isopropyl alcohol;

DOI:10.1016/j.catcom.2012.11.020

Reference yield: 89.0%

methyl (1R,2R)-2-aminocyclohexylcarbamate hydrochloride (1257517-07-9) + p-toluenesulfonyl chloride (98-59-9) → C15H22N2O4S (1257292-59-3)

Guidance literature:

With sodium carbonate; In water; ethyl acetate; at 20 ℃; for 0.5h;

DOI:10.1021/jo101723v

upstream raw materials:

methanol

(3aR,7aR)-1,3,3a,4,5,6,7,7a-octahydrobenzimidazol-2-one

(1R,2R)-1,2-diaminocyclohexane

Downstream raw materials:

methyl ((1R,2R)-2-aminocyclohexyl)carbamate

C₁₅H₂₂N₂O₄S

C₁₅H₂₀N₂O₃

C₁₆H₂₂N₂O₄