(4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)methanol

Base Information

Chemical Name:(4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)methanol
CAS No.:930110-36-4
Molecular Formula:C₁₈H₁₄Cl₂F₃NO₂
Molecular Weight:404.216
Hs Code.:

Synonyms:(4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)methanol

Chemical Property:

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Technology Process of (4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)methanol

There total 6 articles about (4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 864725-62-2
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

: 930110-36-4
(4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)methanol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 - 25 ℃; for 18h;

Reference yield:

: 864736-32-3
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester

: 930110-36-4
(4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)methanol

Guidance literature:: 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Cooling with ice;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 1095275-08-3
4-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl)-2-methylbenzoate triethylamine

: 930110-36-4
(4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; acetic anhydride / 9 h / 60 °C

2: tetrabutylammomium bromide; sodium hydroxide; hydroxylamine / toluene; water / 0 °C

3: borane-THF / tetrahydrofuran / 18 h / 0 - 25 °C

With dmap; borane-THF; tetrabutylammomium bromide; hydroxylamine; acetic anhydride; sodium hydroxide; In tetrahydrofuran; water; toluene;