[7-(4-Cyano-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester

Base Information

Chemical Name:[7-(4-Cyano-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester
CAS No.:214401-42-0
Molecular Formula:C₂₂H₂₃NO₃
Molecular Weight:349.43
Hs Code.:

Synonyms:[7-(4-Cyano-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester

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Chemical Property of [7-(4-Cyano-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester

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Technology Process of [7-(4-Cyano-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester

There total 8 articles about [7-(4-Cyano-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 17201-43-3
4-cyanobenzyl bromide

: 214401-41-9
(7-hydroxy-1,2,3,4-tetrahydro-napthalen-2-yl)-acetic acid ethyl ester

: 214401-42-0
[7-(4-Cyano-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In butanone; for 3h; Heating;
DOI:10.1021/jm9801859

Reference yield:

: 60573-58-2
7-methoxy-3,4-dihydronaphthalene

: 214401-42-0
[7-(4-Cyano-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / 10percent aq. NaHCO₃, 3-chloroperbenzoic acid / toluene / 2 h / Ambient temperature

2: 74 percent / ZnI₂ / benzene / 3 h / Heating

3: 1.) NaH / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

4: 95 percent / H₂ / 10percent Pd/C / methanol / 2 h / 750.06 Torr

5: 55 percent / NaI, TMSCl / acetonitrile / 6 h / Heating

6: 95 percent / K₂CO₃ / butan-2-one / 3 h / Heating

With chloro-trimethyl-silane; hydrogen; sodium hydride; sodium hydrogencarbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; zinc(II) iodide; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; toluene; acetonitrile; butanone; benzene;
DOI:10.1021/jm9801859

Reference yield:

: 4133-34-0
7-methoxyl-2-tetralone

: 214401-42-0
[7-(4-Cyano-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

2: 95 percent / H₂ / 10percent Pd/C / methanol / 2 h / 750.06 Torr

3: 55 percent / NaI, TMSCl / acetonitrile / 6 h / Heating

4: 95 percent / K₂CO₃ / butan-2-one / 3 h / Heating

With chloro-trimethyl-silane; hydrogen; sodium hydride; potassium carbonate; sodium iodide; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; acetonitrile; butanone;
DOI:10.1021/jm9801859