C₁₀H₇BrN₂O₄

Base Information

• Chemical Name: C₁₀H₇BrN₂O₄
• CAS No.: 1632995-69-7
• Molecular Formula: C₁₀H₇BrN₂O₄
• Molecular Weight: 299.081
• Mol file: 1632995-69-7.mol

Synonyms:C₁₀H₇BrN₂O₄

Chemical Property of C₁₀H₇BrN₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₇BrN₂O₄

There total 1 articles about C₁₀H₇BrN₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 6-amino-5-bromopyridine-3-carboxylate (180340-70-9) + malonic acid bis-(2,4,6-trichloro-phenyl) ester (15781-70-1) → C10H7BrN2O4 (1632995-69-7)

Guidance literature:

In toluene; at 90 ℃;

DOI:10.1016/j.bmcl.2014.07.007

Reference yield:

C10H7BrN2O4 (1632995-69-7) → C30H41FN4O5Si

Guidance literature:

Multi-step reaction with 8 steps

1: triethylamine / tetrahydrofuran / 10 - 20 °C

2: tetrahydrofuran / 50 °C

3: sodium hydroxide / water / 1 h / 70 °C

4: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate / water; N,N-dimethyl-formamide / 3 h / 80 - 135 °C

5: hydrogenchloride / water

6: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol; dichloromethane / 0.25 h / 15 °C

7: N-ethyl-N,N-diisopropylamine; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane

8: 1,1'-azodicarbonyl-dipiperidine; triphenylphosphine / dichloromethane / 16 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride heptahydrate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 4: |Heck Reaction / 5: |Heck Reaction / 6: |Luche Cerium Reduction / 8: |Mitsunobu Displacement;

DOI:10.1016/j.bmcl.2014.07.007

Reference yield:

C10H7BrN2O4 (1632995-69-7) → C25H30N4O5 (1622905-90-1)

Guidance literature:

Multi-step reaction with 9 steps

1: triethylamine / tetrahydrofuran / 10 - 20 °C

2: tetrahydrofuran / 50 °C

3: sodium hydroxide / water / 1 h / 70 °C

4: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate / water; N,N-dimethyl-formamide / 3 h / 80 - 135 °C

5: hydrogenchloride / water

6: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol; dichloromethane / 0.25 h / 15 °C

7: N-ethyl-N,N-diisopropylamine; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane

8: 1,1'-azodicarbonyl-dipiperidine; triphenylphosphine / dichloromethane / 16 h / Reflux

9: trifluoroacetic acid / dichloromethane

With hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride heptahydrate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 4: |Heck Reaction / 5: |Heck Reaction / 6: |Luche Cerium Reduction / 8: |Mitsunobu Displacement;

DOI:10.1016/j.bmcl.2014.07.007

upstream raw materials:

methyl 6-amino-5-bromopyridine-3-carboxylate

malonic acid bis-(2,4,6-trichloro-phenyl) ester

Downstream raw materials:

C₂₃H₂₇N₅O₃

C₂₄H₂₉N₅O₄

C₂₅H₂₉N₅O₄

C₂₄H₂₇N₅O₅