3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate

Base Information

• Chemical Name: 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate
• CAS No.: 130856-82-5
• Molecular Formula: C₄₄H₄₉N₄O₁₅P
• Molecular Weight: 904.865
• Mol file: 130856-82-5.mol

Synonyms:3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate

Chemical Property of 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate

There total 10 articles about 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C44H49N4O14PS (151852-35-6) → 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate (130856-82-5)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1016/S0040-4039(00)94505-2

Reference yield:

3'-O-acetylthymidine (21090-30-2) → 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate (130856-82-5)

Guidance literature:

Multi-step reaction with 4 steps

1: DBU / acetonitrile

2: acetonitrile

3: 75 percent / 25percent aq. AgF / acetonitrile / 0.08 h

4: Et₃N

With silver fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In acetonitrile;

DOI:10.1039/c39950000613

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-thymidine-3'-O-(2-seleno-1,3,2-oxathiaphospholane) (145498-72-2) → 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate (130856-82-5)

Guidance literature:

Multi-step reaction with 4 steps

1: DBU / acetonitrile

2: acetonitrile

3: 75 percent / 25percent aq. AgF / acetonitrile / 0.08 h

4: Et₃N

With silver fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In acetonitrile;

DOI:10.1039/c39950000613

upstream raw materials:

C₄₄H₄₉N₄O₁₄PS

3'-O-acetylthymidine

[5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite

(CH₃OC₆H₄)2C₆H₅COCH₃CO₂(C₅H₇OC₅N₂H₅O₂)2O₂POCH₃

Downstream raw materials:

C₄₂H₄₇N₄O₁₄P

C₃₀H₃₉N₅O₁₇P₂

C₅₁H₅₇N₅O₁₉P₂