[trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexyl]methanol

Base Information

• Chemical Name: [trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexyl]methanol
• CAS No.: 1233224-64-0
• Molecular Formula: C₁₆H₂₃NO₃
• Molecular Weight: 277.364
• Mol file: 1233224-64-0.mol

Synonyms:[trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexyl]methanol

Chemical Property of [trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexyl]methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexyl]methanol

There total 2 articles about [trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

trans-[4-(aminomethyl)cyclohexyl]methanol (17879-23-1) + benzyl chloroformate (501-53-1,94274-21-2) → [trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexyl]methanol (1233224-64-0)

Guidance literature:

With sodium carbonate; In water; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.03.085

Reference yield:

trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8) → [trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexyl]methanol (1233224-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere; Reflux

2: sodium carbonate / water / 0 - 20 °C

With lithium aluminium tetrahydride; sodium carbonate; In tetrahydrofuran; water;

DOI:10.1016/j.steroids.2012.07.010

Reference yield: 49.0%

[trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexyl]methanol (1233224-64-0) + adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) → 9-[trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexylmethyl]adenine (1233224-68-4)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2010.03.085

upstream raw materials:

trans-[4-(aminomethyl)cyclohexyl]methanol

benzyl chloroformate

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Downstream raw materials:

9-[trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexylmethyl]adenine

9-(trans-4-aminomethylcyclohexylmethyl)adenine