5-(4-methylphenylsulfonyl)-5,6,7,10,11,12-hexahydro-4H-cyclopenta[c][1,4]diazepino[6,7,1-ij]quinolin-8-ium iodide

Base Information

Chemical Name:5-(4-methylphenylsulfonyl)-5,6,7,10,11,12-hexahydro-4H-cyclopenta[c][1,4]diazepino[6,7,1-ij]quinolin-8-ium iodide
CAS No.:1442654-20-7
Molecular Formula:C₂₂H₂₃N₂O₂S*I
Molecular Weight:506.407
Hs Code.:

Synonyms:5-(4-methylphenylsulfonyl)-5,6,7,10,11,12-hexahydro-4H-cyclopenta[c][1,4]diazepino[6,7,1-ij]quinolin-8-ium iodide

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Chemical Property of 5-(4-methylphenylsulfonyl)-5,6,7,10,11,12-hexahydro-4H-cyclopenta[c][1,4]diazepino[6,7,1-ij]quinolin-8-ium iodide

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Technology Process of 5-(4-methylphenylsulfonyl)-5,6,7,10,11,12-hexahydro-4H-cyclopenta[c][1,4]diazepino[6,7,1-ij]quinolin-8-ium iodide

There total 3 articles about 5-(4-methylphenylsulfonyl)-5,6,7,10,11,12-hexahydro-4H-cyclopenta[c][1,4]diazepino[6,7,1-ij]quinolin-8-ium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 120-92-3
cyclopentanone

: 93019-52-4
4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

: 1442654-20-7
5-(4-methylphenylsulfonyl)-5,6,7,10,11,12-hexahydro-4H-cyclopenta[c][1,4]diazepino[6,7,1-ij]quinolin-8-ium iodide

Guidance literature:: With hydrogen iodide; iodine; In methanol; at 30 ℃; for 12h;
DOI:10.1021/ol401029k

Reference yield:

: 5177-43-5
2,3,4,5-tetrahydro-1H-benzodiazepine dihydrochloride

: 1442654-20-7
5-(4-methylphenylsulfonyl)-5,6,7,10,11,12-hexahydro-4H-cyclopenta[c][1,4]diazepino[6,7,1-ij]quinolin-8-ium iodide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / ethyl acetate; water

1.2: 3.33 h / 20 °C

2.1: iodine; hydrogen iodide / methanol / 12 h / 30 °C

With hydrogen iodide; iodine; sodium hydrogencarbonate; In methanol; water; ethyl acetate;
DOI:10.1021/ol401029k

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1442654-20-7
5-(4-methylphenylsulfonyl)-5,6,7,10,11,12-hexahydro-4H-cyclopenta[c][1,4]diazepino[6,7,1-ij]quinolin-8-ium iodide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / ethyl acetate; water

1.2: 3.33 h / 20 °C

2.1: iodine; hydrogen iodide / methanol / 12 h / 30 °C

With hydrogen iodide; iodine; sodium hydrogencarbonate; In methanol; water; ethyl acetate;
DOI:10.1021/ol401029k