(R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Base Information

Chemical Name:(R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate
CAS No.:1541199-39-6
Molecular Formula:C₁₅H₁₉ClF₃NO₂
Molecular Weight:337.77
Hs Code.:

Synonyms:(R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Suppliers and Price of (R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

There total 7 articles about (R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541198-35-9
rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

: 1541199-38-5
(S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

: 1541199-39-6
(R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Guidance literature:: rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate; With potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide; In water; at 20 ℃; for 168h; pH=8.32; Enzymatic reaction;

In tert-butyl methyl ether; water; at 20 ℃; for 0.25h;

Reference yield:

: 1541198-39-3
C₁₁H₁₀ClF₃O

: 1541199-38-5
(S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

: 1541199-39-6
(R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate / ethanol / 7 h / 80 °C

2.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 168 h / 20 °C / pH 8.32 / Enzymatic reaction

2.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; Amano Lipase PS; ammonium acetate; sodium hydroxide; In ethanol; water;

Reference yield:

: 154257-85-9
1-(3-bromo-5-chlorophenyl)ethan-1-one

: 1541199-38-5
(S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

: 1541199-39-6
(R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.1: dichloromethane; toluene / 8 h / -78 - 25 °C / Inert atmosphere

4.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

4.2: 0.5 h / 20 °C / Inert atmosphere

5.1: ammonium acetate / ethanol / 7 h / 80 °C

6.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 168 h / 20 °C / pH 8.32 / Enzymatic reaction

6.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; ammonium acetate; tetrabutyl ammonium fluoride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; di-isopropyl ether; water; toluene;