(S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

Base Information

Chemical Name:(S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid
CAS No.:1541199-38-5
Molecular Formula:C₁₃H₁₅ClF₃NO₂
Molecular Weight:309.716
Hs Code.:

Synonyms:(S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

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Chemical Property of (S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

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Technology Process of (S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

There total 7 articles about (S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541198-35-9
rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

: 1541199-38-5
(S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

: 1541199-39-6
(R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Guidance literature:: rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate; With potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide; In water; at 20 ℃; for 168h; pH=8.32; Enzymatic reaction;

In tert-butyl methyl ether; water; at 20 ℃; for 0.25h;

Reference yield:

: 1541198-39-3
C₁₁H₁₀ClF₃O

: 1541199-38-5
(S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

: 1541199-39-6
(R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate / ethanol / 7 h / 80 °C

2.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 168 h / 20 °C / pH 8.32 / Enzymatic reaction

2.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; Amano Lipase PS; ammonium acetate; sodium hydroxide; In ethanol; water;

Reference yield:

: 154257-85-9
1-(3-bromo-5-chlorophenyl)ethan-1-one

: 1541199-38-5
(S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

: 1541199-39-6
(R)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.1: dichloromethane; toluene / 8 h / -78 - 25 °C / Inert atmosphere

4.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

4.2: 0.5 h / 20 °C / Inert atmosphere

5.1: ammonium acetate / ethanol / 7 h / 80 °C

6.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 168 h / 20 °C / pH 8.32 / Enzymatic reaction

6.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; ammonium acetate; tetrabutyl ammonium fluoride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; di-isopropyl ether; water; toluene;