rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Base Information

Chemical Name:rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate
CAS No.:1541198-35-9
Molecular Formula:C₁₅H₁₉ClF₃NO₂
Molecular Weight:337.77
Hs Code.:

Synonyms:rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

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Chemical Property of rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

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Technology Process of rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

There total 6 articles about rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071-46-1
hydrogen ethyl malonate

: 1541198-39-3
C₁₁H₁₀ClF₃O

: 1541198-35-9
rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Guidance literature:: With ammonium acetate; In ethanol; at 80 ℃; for 7h;

Reference yield:

: 1541198-37-1
C₁₀H₉BrClF₃O₃S

: 1541198-35-9
rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane; toluene / 8 h / -78 - 25 °C / Inert atmosphere

2.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / ethanol / 7 h / 80 °C

With n-butyllithium; ammonium acetate; In ethanol; hexane; dichloromethane; di-isopropyl ether; toluene;

Reference yield:

: 1352062-44-2
C₉H₇BrClF₃O

: 1541198-35-9
rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: dichloromethane; toluene / 8 h / -78 - 25 °C / Inert atmosphere

3.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: ammonium acetate / ethanol / 7 h / 80 °C

With n-butyllithium; ammonium acetate; triethylamine; In ethanol; hexane; dichloromethane; di-isopropyl ether; toluene;