3-{[(2S,4S)-1-(Diisopropoxy-phosphoryl)-4-mercapto-pyrrolidine-2-carbonyl]-amino}-benzoic acid

Base Information

Chemical Name:3-{[(2S,4S)-1-(Diisopropoxy-phosphoryl)-4-mercapto-pyrrolidine-2-carbonyl]-amino}-benzoic acid
CAS No.:220031-86-7
Molecular Formula:C₁₈H₂₇N₂O₆PS
Molecular Weight:430.462
Hs Code.:

Synonyms:3-{[(2S,4S)-1-(Diisopropoxy-phosphoryl)-4-mercapto-pyrrolidine-2-carbonyl]-amino}-benzoic acid

Suppliers and Price of 3-{[(2S,4S)-1-(Diisopropoxy-phosphoryl)-4-mercapto-pyrrolidine-2-carbonyl]-amino}-benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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TRC
3-[[[(2S,4S)-1-[Bis(1-Methylethoxy)phosphinyl]-4-mercapto-2-pyrrolidinyl]carbonyl]amino]benzoicAcid
10mg
$ 1320.00

Total 6 raw suppliers

Chemical Property of 3-{[(2S,4S)-1-(Diisopropoxy-phosphoryl)-4-mercapto-pyrrolidine-2-carbonyl]-amino}-benzoic acid

Chemical Property:

Purity/Quality:

> 95% ^*data from raw suppliers

3-[[[(2S,4S)-1-[Bis(1-Methylethoxy)phosphinyl]-4-mercapto-2-pyrrolidinyl]carbonyl]amino]benzoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3-[[[(2S,4S)-1-[Bis(1-Methylethoxy)phosphinyl]-4-mercapto-2-pyrrolidinyl]carbonyl]amino]benzoic Acid, is an impurity of Ertapenem (E635000), Group 1 carbapenem antibiotic. An antibacterial.

Technology Process of 3-{[(2S,4S)-1-(Diisopropoxy-phosphoryl)-4-mercapto-pyrrolidine-2-carbonyl]-amino}-benzoic acid

There total 4 articles about 3-{[(2S,4S)-1-(Diisopropoxy-phosphoryl)-4-mercapto-pyrrolidine-2-carbonyl]-amino}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117286-92-7
N‐(O,O‐diisopropylphosphoryl)-trans-4‐hydroxy-L-proline

: 220031-86-7
3-{[(2S,4S)-1-(Diisopropoxy-phosphoryl)-4-mercapto-pyrrolidine-2-carbonyl]-amino}-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 56 percent / (i-Pr)2NEt / CH₂Cl₂ / 0.25 h / -15 °C

2.1: pyridine / CH₂Cl₂ / 0.5 h / -20 °C

3.1: Na₂S*3H₂O / CH₂Cl₂; H₂O / 0.03 h

3.2: 5 g / CH₂Cl₂; H₂O / 2.08 h / 3 - 25 °C

4.1: acetic acid / 20 - 23 °C

With pyridine; sodium sulfide; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetic acid;
DOI:10.1021/jo011170c

Reference yield:

: 266337-23-9
(2S-trans)-1-[bis(1-methylethoxy)phosphinyl]tetrahydro-4-hydroxy-2H-pyrrole-2-carboxylic acid diphenylphosphinyl ester

: 220031-86-7
3-{[(2S,4S)-1-(Diisopropoxy-phosphoryl)-4-mercapto-pyrrolidine-2-carbonyl]-amino}-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / CH₂Cl₂ / 0.5 h / -20 °C

2.1: Na₂S*3H₂O / CH₂Cl₂; H₂O / 0.03 h

2.2: 5 g / CH₂Cl₂; H₂O / 2.08 h / 3 - 25 °C

3.1: acetic acid / 20 - 23 °C

With pyridine; sodium sulfide; In dichloromethane; water; acetic acid;
DOI:10.1021/jo011170c

Reference yield:

: 266337-24-0
C₂₄H₃₃NO₉P₂S

: 220031-86-7
3-{[(2S,4S)-1-(Diisopropoxy-phosphoryl)-4-mercapto-pyrrolidine-2-carbonyl]-amino}-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: Na₂S*3H₂O / CH₂Cl₂; H₂O / 0.03 h

1.2: 5 g / CH₂Cl₂; H₂O / 2.08 h / 3 - 25 °C

2.1: acetic acid / 20 - 23 °C

With sodium sulfide; In dichloromethane; water; acetic acid;
DOI:10.1021/jo011170c