(2S-trans)-1-[bis(1-methylethoxy)phosphinyl]tetrahydro-4-hydroxy-2H-pyrrole-2-carboxylic acid diphenylphosphinyl ester

Base Information

Chemical Name:(2S-trans)-1-[bis(1-methylethoxy)phosphinyl]tetrahydro-4-hydroxy-2H-pyrrole-2-carboxylic acid diphenylphosphinyl ester
CAS No.:266337-23-9
Molecular Formula:C₂₃H₃₁NO₇P₂
Molecular Weight:495.449
Hs Code.:

Synonyms:(2S-trans)-1-[bis(1-methylethoxy)phosphinyl]tetrahydro-4-hydroxy-2H-pyrrole-2-carboxylic acid diphenylphosphinyl ester

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Chemical Property of (2S-trans)-1-[bis(1-methylethoxy)phosphinyl]tetrahydro-4-hydroxy-2H-pyrrole-2-carboxylic acid diphenylphosphinyl ester

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Technology Process of (2S-trans)-1-[bis(1-methylethoxy)phosphinyl]tetrahydro-4-hydroxy-2H-pyrrole-2-carboxylic acid diphenylphosphinyl ester

There total 1 articles about (2S-trans)-1-[bis(1-methylethoxy)phosphinyl]tetrahydro-4-hydroxy-2H-pyrrole-2-carboxylic acid diphenylphosphinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 117286-92-7
N‐(O,O‐diisopropylphosphoryl)-trans-4‐hydroxy-L-proline

: 1499-21-4
Diphenylphosphinic chloride

: 266337-23-9
(2S-trans)-1-[bis(1-methylethoxy)phosphinyl]tetrahydro-4-hydroxy-2H-pyrrole-2-carboxylic acid diphenylphosphinyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -15 ℃; for 0.25h;
DOI:10.1021/jo011170c

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 266337-23-9
(2S-trans)-1-[bis(1-methylethoxy)phosphinyl]tetrahydro-4-hydroxy-2H-pyrrole-2-carboxylic acid diphenylphosphinyl ester

: 266337-24-0
C₂₄H₃₃NO₉P₂S

Guidance literature:: With pyridine; In dichloromethane; at -20 ℃; for 0.5h;
DOI:10.1021/jo011170c

Reference yield:

: 266337-23-9
(2S-trans)-1-[bis(1-methylethoxy)phosphinyl]tetrahydro-4-hydroxy-2H-pyrrole-2-carboxylic acid diphenylphosphinyl ester

: 444057-64-1
(2S)-cis-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]amino]benzoic acid monohydrochloride disulfide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / CH₂Cl₂ / 0.5 h / -20 °C

2.1: Na₂S*3H₂O / CH₂Cl₂; H₂O / 0.03 h

2.2: 5 g / CH₂Cl₂; H₂O / 2.08 h / 3 - 25 °C

3.1: acetic acid / 20 - 23 °C

4.1: 1.88 kg / conc. HCl / acetic acid / 2 h / 20 - 23 °C

5.1: dimethylsulfoxide / 48 h / 20 °C

With pyridine; hydrogenchloride; sodium sulfide; In dichloromethane; water; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jo011170c