Dansyl hydrazine

Base Information

• Chemical Name: Dansyl hydrazine
• CAS No.: 33008-06-9
• Molecular Formula: C12H15 N3 O2 S
• Molecular Weight: 265.336
• Hs Code.: 32049010
• European Community (EC) Number: 251-337-7
• DSSTox Substance ID: DTXSID90186640
• Nikkaji Number: J207.994A
• Wikidata: Q83057994
• Mol file: 33008-06-9.mol

Synonyms:dansyl hydrazine;dansylhydrazine

Chemical Property of Dansyl hydrazine

Chemical Property:

• Vapor Pressure: 2.57E-08mmHg at 25°C
• Melting Point: 126-130 °C(lit.)
• Boiling Point: 450.8°Cat760mmHg
• PKA: 9.31±0.40(Predicted)
• Flash Point: 226.4°C
• PSA: 83.81000
• Density: 1.331g/cm³
• LogP: 3.22980
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Solubility.: ethanol: soluble
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 265.08849790
• Heavy Atom Count: 18
• Complexity: 377

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dansylhydrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydrazides
• Canonical SMILES: CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)NN
• Uses: Dansylhydrazine (DH) is widely used as a fluorometric reagent for carbonyl compounds. Dansylated carbonyl molecules can be separated and identified by analytical techniques. Dansylhydrazine can exhibit fluorescence, which can be used for the following:monitoring air pollution by detection of the hydrazones formed by acid-catalyzed derivatization of the carbonyl compoundsdetection of the separated glycoproteins via sodium dodecyl sulfate polyacrylamide gel electrophoresis(SDS-PAGE)

Technology Process of Dansyl hydrazine

There total 4 articles about Dansyl hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-(dimethylamino)naphth-1-ylsulfonyl chloride (605-65-2) → dansyl hydrazine (33008-06-9)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1021/acs.inorgchem.5b01284

Reference yield:

C20H27N3O4S → 7-oxooctanoic acid (14112-98-2) + dansyl hydrazine (33008-06-9)

Guidance literature:

With water; Neutral conditions;

DOI:10.1021/ac3028728

Reference yield:

C17H23N3O3S → 5-Hydroxy-2-pentanone (1071-73-4) + dansyl hydrazine (33008-06-9)

Guidance literature:

With water; Neutral conditions;

DOI:10.1021/ac3028728

upstream raw materials:

5-(dimethylamino)naphth-1-ylsulfonyl chloride

Downstream raw materials:

Boc-Leu-NHNHDns

Refernces

• 1、 Basu, Sudipta,Biswas, Ankur,Lahiri, Mayurika,Pandey, Shalini,Sharma, Virender Kumar. "Small molecule-mediated induction of endoplasmic reticulum stress in cancer cells". supporting information. p. 1604 - 1611. Retrieved 2021/10/23.
• 2、 Kalafut-Pettibone, Alicia J,McGivern, W. Sean. "Analytical methodology for determination of organic aerosol functional group distributions". . p. 3553 - 3560. Retrieved 2013/05/22.