2-(4-methylbenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole

Base Information

• Chemical Name: 2-(4-methylbenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole
• CAS No.: 1310578-65-4
• Molecular Formula: C₁₈H₁₄FN₃S
• Molecular Weight: 323.394

Synonyms:2-(4-methylbenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole

Chemical Property of 2-(4-methylbenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole

Chemical Property:

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Technology Process of 2-(4-methylbenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole

There total 2 articles about 2-(4-methylbenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-bromo-4'-fluoroacetophenone (403-29-2) + 2-amino-5-(4-methylbenzyl)-1,3,4-thiadiazole (39181-45-8) → 2-(4-methylbenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole (1310578-65-4)

Guidance literature:

2-bromo-4'-fluoroacetophenone; 2-amino-5-(4-methylbenzyl)-1,3,4-thiadiazole; In ethanol; Reflux;

With sodium carbonate; In water; Cooling;

DOI:10.1016/j.ejmech.2011.02.064

Reference yield:

4-tolylacetic acid (622-47-9) → 2-(4-methylbenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole (1310578-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 80 °C / Cooling with ice

2.1: ethanol / Reflux

2.2: Cooling

With sulfuric acid; In ethanol;

DOI:10.1016/j.ejmech.2011.02.064

Reference yield: 67.0%

2-(4-methylbenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole (1310578-65-4) → 2-(4-methylbenzyl)-5-bromo-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole (1310578-69-8)

Guidance literature:

With bromine; sodium acetate; acetic acid; at 20 ℃;

DOI:10.1016/j.ejmech.2011.02.064

upstream raw materials:

4-tolylacetic acid

2-bromo-4'-fluoroacetophenone

2-amino-5-(4-methylbenzyl)-1,3,4-thiadiazole

Downstream raw materials:

2-(4-methylbenzyl)-5-bromo-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole

2-(4-methylbenzyl)-5-thiocyanato-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole

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