N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

Base Information

Chemical Name:N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester
CAS No.:168070-05-1
Molecular Formula:C₄₃H₆₃N₃O₁₀
Molecular Weight:781.987
Hs Code.:

Synonyms:N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

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Chemical Property of N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

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Technology Process of N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

There total 16 articles about N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 55739-21-4
N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-OH

: 168070-04-0
H-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

: 168070-05-1
N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; at 0 ℃;
DOI:10.1016/S0960-894X(99)00038-4

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 168070-05-1
N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / PhI(OAc)2, I₂ / -10 °C

2: EDCI, DMAP, TEA

3: H₂ / 10 percent Pd/C / methanol; ethyl acetate

4: 89 percent / PyBroP, DIEA / 0 °C

With dmap; [bis(acetoxy)iodo]benzene; TEA; hydrogen; iodine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/S0960-894X(99)00038-4

Reference yield:

: 13748-90-8,498-36-2
(S)-2-hydroxyl-3,3-dimethylbutyric acid

: 168070-05-1
N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / PhI(OAc)2, I₂ / -10 °C

2: EDCI, DMAP, TEA

3: H₂ / 10 percent Pd/C / methanol; ethyl acetate

4: 84 percent / BOP-Cl, NMM

5: 95 percent / TFA / -10 °C

6: 89 percent / PyBroP, DIEA / 0 °C

With 4-methyl-morpholine; dmap; [bis(acetoxy)iodo]benzene; TEA; hydrogen; iodine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/S0960-894X(99)00038-4