3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride

Base Information

Chemical Name:3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride
CAS No.:1418026-00-2
Molecular Formula:C₁₈H₁₅ClN₂O₃*ClH
Molecular Weight:379.243
Hs Code.:

Synonyms:3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride

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Chemical Property of 3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride

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Technology Process of 3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride

There total 9 articles about 3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

: 1418025-99-6
3-azidomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

: 1418026-00-2
3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; platinum(IV) oxide; hydrogen; In ethyl acetate; 1,2-dichloro-ethane; at 20 ℃; for 4h; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 1402345-30-5
4-chloro-N-methoxy-N-methyl-2-phenylamino-benzamide

: 1418026-00-2
3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2: toluene / 16 h / 110 °C / 760.05 Torr / Inert atmosphere

3: potassium carbonate / methanol / 1 h / 80 °C / 760.05 Torr / Inert atmosphere

4: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / 100 °C / 760.05 Torr / Inert atmosphere

5: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

6: platinum(IV) oxide; hydrogen; hydrogenchloride / ethyl acetate; 1,2-dichloro-ethane / 4 h / 20 °C / 760.05 Torr / Inert atmosphere

With hydrogenchloride; platinum(IV) oxide; N-Bromosuccinimide; sodium azide; hydrogen; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1402345-31-6
1-(4-chloro-2-phenylamino-phenyl)propan-1-one

: 1418026-00-2
3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 16 h / 110 °C / 760.05 Torr / Inert atmosphere

2: potassium carbonate / methanol / 1 h / 80 °C / 760.05 Torr / Inert atmosphere

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / 100 °C / 760.05 Torr / Inert atmosphere

4: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

5: platinum(IV) oxide; hydrogen; hydrogenchloride / ethyl acetate; 1,2-dichloro-ethane / 4 h / 20 °C / 760.05 Torr / Inert atmosphere

With hydrogenchloride; platinum(IV) oxide; N-Bromosuccinimide; sodium azide; hydrogen; potassium carbonate; dibenzoyl peroxide; In methanol; tetrachloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;