7-chloro-3-[(4-chloro-benzoylamino)methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Base Information

Chemical Name:7-chloro-3-[(4-chloro-benzoylamino)methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester
CAS No.:1418024-86-8
Molecular Formula:C₂₅H₁₈Cl₂N₂O₄
Molecular Weight:481.335
Hs Code.:

Synonyms:7-chloro-3-[(4-chloro-benzoylamino)methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

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Chemical Property of 7-chloro-3-[(4-chloro-benzoylamino)methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

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Technology Process of 7-chloro-3-[(4-chloro-benzoylamino)methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

There total 10 articles about 7-chloro-3-[(4-chloro-benzoylamino)methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1418026-00-2
3-aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride

: 122-01-0
4-chloro-benzoyl chloride

: 1418024-86-8
7-chloro-3-[(4-chloro-benzoylamino)methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 1402345-30-5
4-chloro-N-methoxy-N-methyl-2-phenylamino-benzamide

: 1418024-86-8
7-chloro-3-[(4-chloro-benzoylamino)methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2: toluene / 16 h / 110 °C / 760.05 Torr / Inert atmosphere

3: potassium carbonate / methanol / 1 h / 80 °C / 760.05 Torr / Inert atmosphere

4: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / 100 °C / 760.05 Torr / Inert atmosphere

5: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

6: platinum(IV) oxide; hydrogen; hydrogenchloride / ethyl acetate; 1,2-dichloro-ethane / 4 h / 20 °C / 760.05 Torr / Inert atmosphere

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / 760.05 Torr / Inert atmosphere

With hydrogenchloride; platinum(IV) oxide; N-Bromosuccinimide; sodium azide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1402345-31-6
1-(4-chloro-2-phenylamino-phenyl)propan-1-one

: 1418024-86-8
7-chloro-3-[(4-chloro-benzoylamino)methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 16 h / 110 °C / 760.05 Torr / Inert atmosphere

2: potassium carbonate / methanol / 1 h / 80 °C / 760.05 Torr / Inert atmosphere

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / 100 °C / 760.05 Torr / Inert atmosphere

4: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

5: platinum(IV) oxide; hydrogen; hydrogenchloride / ethyl acetate; 1,2-dichloro-ethane / 4 h / 20 °C / 760.05 Torr / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / 760.05 Torr / Inert atmosphere

With hydrogenchloride; platinum(IV) oxide; N-Bromosuccinimide; sodium azide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In methanol; tetrachloromethane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;