β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester

Base Information

Chemical Name:β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester
CAS No.:195302-00-2
Molecular Formula:C₄₆H₅₃N₅O₁₂
Molecular Weight:867.953
Hs Code.:

Synonyms:β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester

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Chemical Property of β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester

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Technology Process of β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester

There total 4 articles about β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 195301-96-3
β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[(2R)-aspartate] diester

: 195302-00-2
β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester

Guidance literature:: With potassium carbonate; In diethyl ether; at 0 ℃; for 1h;
DOI:10.1039/b100401h

Reference yield:

: 368443-68-9
α-methyl γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate

: 195302-00-2
β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / PhSiH₃ / (Ph₃P)4Pd⁽⁰⁾ / CH₂Cl₂ / 2 h / 20 °C

2: 100 percent / aq. K₂CO₃ / diethyl ether / 1 h / 0 °C

With phenylsilane; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane;
DOI:10.1039/b100401h

Reference yield:

: 204251-33-2
γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate

: 195302-00-2
β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / diethyl ether / 1 h / 0 °C

2: 81 percent / PhSiH₃ / (Ph₃P)4Pd⁽⁰⁾ / CH₂Cl₂ / 2 h / 20 °C

3: 100 percent / aq. K₂CO₃ / diethyl ether / 1 h / 0 °C

With phenylsilane; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane;
DOI:10.1039/b100401h