1-(3-fluoro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

Base Information

Chemical Name:1-(3-fluoro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea
CAS No.:1261161-47-0
Molecular Formula:C₂₄H₂₃FN₂O₂
Molecular Weight:390.457
Hs Code.:

Synonyms:1-(3-fluoro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

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Chemical Property of 1-(3-fluoro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

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Technology Process of 1-(3-fluoro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

There total 2 articles about 1-(3-fluoro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₁FN₂O₂

: 74-88-4
methyl iodide

: 1261161-47-0
1-(3-fluoro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

Guidance literature:: C₂₃H₂₁FN₂O₂; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol102155h

Reference yield:

: 104937-84-0
N-(p-methoxyphenyl)-α-ethenylbenzenemethaneamine

: 404-71-7
1-fluoro-3-isocyanatobenzene

: 1261161-47-0
1-(3-fluoro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol1027442

Reference yield: 89.0%

: 1261161-47-0
1-(3-fluoro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

: 1256930-31-0
(+/-)-1-(1-(3-fluorophenyl)-1-phenylallyl)-1-(4-methoxyphenyl)-3-methylurea

Guidance literature:: 1-(3-fluoro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

With methanol; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol102155h