Technology Process of C13H16
There total 6 articles about C13H16 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-6-bromo-1,2,3,4-tetrahydro-1,1'-biphenyl;
With
tert.-butyl lithium;
In
tetrahydrofuran;
at -78 ℃;
methyl iodide;
In
tetrahydrofuran;
at -30 ℃;
for 1h;
DOI:10.1055/s-0033-1341065
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1-methyl-1H-imidazole / dichloromethane / 4 h / 20 °C / Cooling with ice
2.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / 0 °C
2.2: 3 h / -40 - 0 °C
3.1: tert.-butyl lithium / tetrahydrofuran / -78 °C
3.2: 1 h / -30 °C
With
1-methyl-1H-imidazole; copper(I) bromide dimethylsulfide complex; tert.-butyl lithium;
In
tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0033-1341065
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 2,5-bis(1,1-dimethylethyl)-1,4-benzenediol; bromine; hydrogen bromide / water; dichloromethane / 0.67 h / 0 °C
1.2: 0.33 h / 20 °C
2.1: (S)-diphenylprolinol; Trimethyl borate; borane N,N-diethylaniline complex / tetrahydrofuran / 4 h / -10 - -2 °C
3.1: 1-methyl-1H-imidazole / dichloromethane / 4 h / 20 °C / Cooling with ice
4.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / 0 °C
4.2: 3 h / -40 - 0 °C
5.1: tert.-butyl lithium / tetrahydrofuran / -78 °C
5.2: 1 h / -30 °C
With
1-methyl-1H-imidazole; borane N,N-diethylaniline complex; copper(I) bromide dimethylsulfide complex; Trimethyl borate; (S)-diphenylprolinol; 2,5-bis(1,1-dimethylethyl)-1,4-benzenediol; hydrogen bromide; bromine; tert.-butyl lithium;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1055/s-0033-1341065
