but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-1-methylbutyl ester

Base Information

Chemical Name:but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-1-methylbutyl ester
CAS No.:942063-02-7
Molecular Formula:C₂₂H₃₆O₃Si
Molecular Weight:376.612
Hs Code.:

Synonyms:but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-1-methylbutyl ester

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Chemical Property of but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-1-methylbutyl ester

Chemical Property:

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Technology Process of but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-1-methylbutyl ester

There total 3 articles about but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-1-methylbutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 942063-01-6
5-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]pentan-2-ol

: 623-68-7
trans-crotonic anhydride

: 942063-02-7
but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-1-methylbutyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/ol0704901

Reference yield:

: 271769-81-4
(1,1-dimethylethyl)[(2-iodophenyl)methoxy]dimethylsilane

: 942063-02-7
but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-1-methylbutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 53 percent / tetra-n-butylammonium bromide; NaOAc; LiCl / Pd(OAc)2 / dimethylformamide / 72 h / 50 °C

2.1: diethyl ether; tetrahydrofuran / 1 h / 0 °C

2.2: 83 percent / NH₄Cl / diethyl ether; tetrahydrofuran; H₂O

3.1: 80 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 0 °C

With dmap; tetrabutylammomium bromide; sodium acetate; triethylamine; lithium chloride; palladium diacetate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0704901

Reference yield:

: 942062-96-6
4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyraldehyde

: 942063-02-7
but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-1-methylbutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl ether; tetrahydrofuran / 1 h / 0 °C

1.2: 83 percent / NH₄Cl / diethyl ether; tetrahydrofuran; H₂O

2.1: 80 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 0 °C

With dmap; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol0704901