2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide

Base Information

Chemical Name:2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide
CAS No.:1245940-91-3
Molecular Formula:C₂₅H₂₂ClF₆N₅O₄
Molecular Weight:605.924
Hs Code.:

2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide

Synonyms:2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide

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Chemical Property of 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide

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Technology Process of 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide

There total 7 articles about 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 959140-61-5
{3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

: 1245940-59-3
2-Amino-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride

: 1245940-91-3
2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide

Guidance literature:: With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1228650-22-3
[3-(4-chlorophenyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]acetic acid

: 1245940-91-3
2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

1.2: 70 °C

2.1: sodium tetrahydroborate / methanol / 1.5 h / Cooling with ice

3.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

4.1: ethyl acetate; 2-Methylpentane / Resolution of racemate

5.1: lithium hydroxide / water; methanol / 1 h / 20 °C

5.2: pH 1 - 2

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium tetrahydroborate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; potassium iodide; lithium hydroxide; In pyridine; methanol; 2-Methylpentane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1245940-91-3
2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 20 - 50 °C

2.1: sodium hydroxide; water / Reflux

2.2: pH 1

3.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: sodium tetrahydroborate / methanol / 1.5 h / Cooling with ice

5.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

6.1: ethyl acetate; 2-Methylpentane / Resolution of racemate

7.1: lithium hydroxide / water; methanol / 1 h / 20 °C

7.2: pH 1 - 2

8.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium tetrahydroborate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; water; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; pyridine; methanol; 2-Methylpentane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;