(R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-<4-(2-propenyloxy)phenyl>acetonitrile

Base Information

• Chemical Name: (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-<4-(2-propenyloxy)phenyl>acetonitrile
• CAS No.: 153225-89-9
• Molecular Formula: C₁₇H₂₅NO₂Si
• Molecular Weight: 303.476
• Mol file: 153225-89-9.mol

Synonyms:(R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-<4-(2-propenyloxy)phenyl>acetonitrile

Chemical Property of (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-<4-(2-propenyloxy)phenyl>acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-<4-(2-propenyloxy)phenyl>acetonitrile

There total 3 articles about (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-<4-(2-propenyloxy)phenyl>acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 2-hydroxy-2-<4-(2-propenyloxy)phenyl>acetonitrile (153225-88-8) → (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-<4-(2-propenyloxy)phenyl>acetonitrile (153225-89-9)

Guidance literature:

With 1H-imidazole;

DOI:10.1016/S0957-4166(00)80062-2

Reference yield:

4-(2-propenyloxy)benzaldehyde (40663-68-1) → (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-<4-(2-propenyloxy)phenyl>acetonitrile (153225-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / (S,S)-cyclo(phenylalanylhistidyl) / toluene / 36 h / -15 °C

2: 97 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

With 1H-imidazole; (S,S)-cyclo(phenylalanylhistidyl); In N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4020(01)85686-6

Reference yield:

(1-(4-(allyloxy)phenyl)-2-nitroethoxy)(tert-butyl)dimethylsilane → 2-(4-(allyloxy)phenyl)-2-((tert-butyldimethylsilyl)oxy)acetonitrile + (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-<4-(2-propenyloxy)phenyl>acetonitrile (153225-89-9)

Guidance literature:

With trichlorosilane; triethylamine; In dichloromethane; at -20 ℃; for 3h; Overall yield = 54 percent; Inert atmosphere;

DOI:10.1002/chem.202100889

upstream raw materials:

tert-butyldimethylsilyl chloride

2-hydroxy-2-<4-(2-propenyloxy)phenyl>acetonitrile

4-(2-propenyloxy)benzaldehyde

Downstream raw materials:

(-)-(α)-<<<2-(3,4-dimethoxyphenyl)ethyl>amino>methyl>-(α)-<(1,1-dimethylethyl)dimethylsilyloxy>-4-(2-propenyloxy)benzenemethane

(-)-(α)-<<<2-(3,4-dimethoxyphenyl)ethyl>amino>methyl>-4-(2-propenyloxy)benzenemethanol

denopamine