tert-butyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate

Base Information

Chemical Name:tert-butyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate
CAS No.:1239018-75-7
Molecular Formula:C₂₄H₂₉FN₄O₅
Molecular Weight:472.516
Hs Code.:

Synonyms:tert-butyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate

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Chemical Property of tert-butyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate

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Technology Process of tert-butyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate

There total 1 articles about tert-butyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239018-74-6
tert-butyl (1-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidin-2-yl)-4-hydroxymethylcyclohexyl)carbamate

: 1239018-75-7
tert-butyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate

Guidance literature:: tert-butyl (1-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidin-2-yl)-4-hydroxymethylcyclohexyl)carbamate; With methanesulfonyl chloride; triethylamine; In ISOPROPYLAMIDE; for 3.25h; Cooling in ice;

With sodium hydroxide; In ISOPROPYLAMIDE; water; at 80 ℃; for 18h; Cooling in ice;

With hydrogenchloride; In ISOPROPYLAMIDE; water; Cooling in ice;

Reference yield:

: 1239018-75-7
tert-butyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate

: 7143-01-3
Methanesulfonic anhydride

: 1239018-76-8
10-tert-butoxycarbonylamino-2-(4-fluorobenzylcarbamoyl)-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepin-3-yl methanesulfonate

Guidance literature:: tert-butyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate; Methanesulfonic anhydride; With triethylamine; In acetonitrile; at 0 - 15 ℃; for 0.5h;

With water; In acetonitrile; at 0 ℃; for 2h;