racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate

Base Information

Chemical Name:racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate
CAS No.:1192063-72-1
Molecular Formula:C₂₁H₃₁NO₃
Molecular Weight:345.482
Hs Code.:

Synonyms:racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate

Suppliers and Price of racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate

There total 1 articles about racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54314-85-1
(3-benzyloxypropyl)triphenylphosphonium bromide

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 1192063-72-1
racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate

Guidance literature:: (3-benzyloxypropyl)triphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃;

tert butyl 4-formylpiperidine-1-carboxylate; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield:

: 593-71-5
Chloroiodomethane

: 1192063-72-1
racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate

: rac-tert-butyl 4-{(1S,2R)-2-[2-(benzyloxy)ethyl]cyclopropyl}piperidine-1-carboxylate

Guidance literature:: Chloroiodomethane; With diethylzinc; In hexane; 1,2-dichloro-ethane; at -20 - -15 ℃; Inert atmosphere;

racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate; In 1,2-dichloro-ethane; at -20 - 20 ℃; Inert atmosphere;

Reference yield:

: 1192063-72-1
racemic tert-butyl 4-[(1Z)-4-(benzyloxy)but-1-en-1-yl]piperidine-1-carboxylate

: C₂₈H₃₂ClN₇O

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethylzinc / hexane; 1,2-dichloro-ethane / -20 - -15 °C / Inert atmosphere

1.2: -20 - 20 °C / Inert atmosphere

2.1: hydrogen / 20 % Pd(OH)2/C / ethyl acetate; ethanol / 1 h / 20 °C / Inert atmosphere

3.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 0.33 h

4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

5.1: trifluoroacetic acid / 0.33 h / 20 °C

6.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.08 h / 20 °C

6.2: 0.5 h / 70 °C

With 1H-imidazole; hydrogen; iodine; diethylzinc; sodium hydride; caesium carbonate; triphenylphosphine; trifluoroacetic acid; 20 % Pd(OH)2/C; In 1-methyl-pyrrolidin-2-one; ethanol; hexane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1.1: Charette cyclopropanation;