ethyl 8-(benzyloxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Base Information

Chemical Name:ethyl 8-(benzyloxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate
CAS No.:221229-92-1
Molecular Formula:C₂₁H₂₂N₂O₃
Molecular Weight:350.417
Hs Code.:

Synonyms:ethyl 8-(benzyloxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

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Chemical Property of ethyl 8-(benzyloxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

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Technology Process of ethyl 8-(benzyloxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

There total 5 articles about ethyl 8-(benzyloxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.9%

: 52068-30-1,55974-70-4
4-benzyloxyphenylhydrazine hydrochloride

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 221229-92-1
ethyl 8-(benzyloxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Guidance literature:: With phosphoric acid; acetic acid; at 80 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.bioorg.2021.105172

Reference yield:

: 1145-76-2
benzyl 4-nitrophenyl ether

: 221229-92-1
ethyl 8-(benzyloxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(II) chloride dihdyrate; hydrogenchloride / ethanol / 9 h / 80 °C

2.1: hydrogenchloride / 1 h / 0 °C

2.2: 3.5 h / 0 - 20 °C

2.3: 0 - 20 °C

3.1: acetic acid; phosphoric acid / 5 h / 80 °C / Inert atmosphere

With hydrogenchloride; tin(II) chloride dihdyrate; phosphoric acid; acetic acid; In ethanol; 3.1: |Fischer Indole Synthesis;
DOI:10.1016/j.bioorg.2021.105172

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 221229-92-1
ethyl 8-(benzyloxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 0 °C

2.1: tin(II) chloride dihdyrate; hydrogenchloride / ethanol / 9 h / 80 °C

3.1: hydrogenchloride / 1 h / 0 °C

3.2: 3.5 h / 0 - 20 °C

3.3: 0 - 20 °C

4.1: acetic acid; phosphoric acid / 5 h / 80 °C / Inert atmosphere

With hydrogenchloride; tin(II) chloride dihdyrate; phosphoric acid; potassium carbonate; acetic acid; In ethanol; N,N-dimethyl-formamide; 4.1: |Fischer Indole Synthesis;
DOI:10.1016/j.bioorg.2021.105172