N-(2-diethylaminoethyl)-4-(N'-methyl-N'-benzyl-2-aminoethyl)benzamide

Base Information

• Chemical Name: N-(2-diethylaminoethyl)-4-(N'-methyl-N'-benzyl-2-aminoethyl)benzamide
• CAS No.: 223768-57-8
• Molecular Formula: C₂₃H₃₃N₃O
• Molecular Weight: 367.535
• Mol file: 223768-57-8.mol

Synonyms:N-(2-diethylaminoethyl)-4-(N'-methyl-N'-benzyl-2-aminoethyl)benzamide

Chemical Property of N-(2-diethylaminoethyl)-4-(N'-methyl-N'-benzyl-2-aminoethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-diethylaminoethyl)-4-(N'-methyl-N'-benzyl-2-aminoethyl)benzamide

There total 4 articles about N-(2-diethylaminoethyl)-4-(N'-methyl-N'-benzyl-2-aminoethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,N-diethylethylenediamine (100-36-7) + methyl 4-(N-methyl-N-benzyl-2-aminoethyl)benzoate (223768-51-2) → N-(2-diethylaminoethyl)-4-(N'-methyl-N'-benzyl-2-aminoethyl)benzamide (223768-57-8)

Guidance literature:

With trimethylaluminum; In hexane; dichloromethane; for 96h; Heating;

DOI:10.1002/(SICI)1099-1344(199904)42:4<325::AID-JLCR193>3.0.CO;2-J

Reference yield:

4-(2-amino-ethyl)-benzoic acid methyl ester (77265-67-9) → N-(2-diethylaminoethyl)-4-(N'-methyl-N'-benzyl-2-aminoethyl)benzamide (223768-57-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / potassium carbonate / acetonitrile / 120 h / 20 °C

2: 68 percent / formic acid / H₂O / 16 h / Heating

3: 99 percent / trimethylaluminium / CH₂Cl₂; hexane / 96 h / Heating

With formic acid; trimethylaluminum; potassium carbonate; In hexane; dichloromethane; water; acetonitrile; 1: Alkylation / 2: Methylation / 3: Condensation;

DOI:10.1002/(SICI)1099-1344(199904)42:4<325::AID-JLCR193>3.0.CO;2-J

Reference yield:

benzyl chloride (100-44-7) → N-(2-diethylaminoethyl)-4-(N'-methyl-N'-benzyl-2-aminoethyl)benzamide (223768-57-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / potassium carbonate / acetonitrile / 120 h / 20 °C

2: 68 percent / formic acid / H₂O / 16 h / Heating

3: 99 percent / trimethylaluminium / CH₂Cl₂; hexane / 96 h / Heating

With formic acid; trimethylaluminum; potassium carbonate; In hexane; dichloromethane; water; acetonitrile; 1: Alkylation / 2: Methylation / 3: Condensation;

DOI:10.1002/(SICI)1099-1344(199904)42:4<325::AID-JLCR193>3.0.CO;2-J

upstream raw materials:

N,N-diethylethylenediamine

methyl 4-(N-methyl-N-benzyl-2-aminoethyl)benzoate

4-(2-amino-ethyl)-benzoic acid methyl ester

benzyl chloride

Downstream raw materials:

N-(2-diethylaminoethyl)-4-(N'-methyl-2-aminoethyl)benzamide