1,2-Ethanediamine,N1,N1-dimethyl-N2-(2-phenyl-4-quinolinyl)-

Base Information

• Chemical Name: 1,2-Ethanediamine,N1,N1-dimethyl-N2-(2-phenyl-4-quinolinyl)-
• CAS No.: 148726-12-9
• Molecular Formula: C19H21 N3
• Molecular Weight: 291.3901
• Mol file: 148726-12-9.mol

Synonyms:1,2-Ethanediamine,N,N-dimethyl-N'-(2-phenyl-4-quinolinyl)- (9CI)

Chemical Property of 1,2-Ethanediamine,N1,N1-dimethyl-N2-(2-phenyl-4-quinolinyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Ethanediamine,N1,N1-dimethyl-N2-(2-phenyl-4-quinolinyl)-

There total 8 articles about 1,2-Ethanediamine,N1,N1-dimethyl-N2-(2-phenyl-4-quinolinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

2-trifluoromethyl-N-(1-phenylethylidene)benzenamine (75040-61-8) + lithium N-<2-(dimethylamino)ethyl>amide (132608-39-0) → 2-amino-N-<2-(dimethylamino)ethyl>benzamide (6725-13-9) + N-<2-(Dimethylamino)ethyl>-2-phenylquinolin-4-amine (148726-12-9)

Guidance literature:

With hydrogenchloride; at 23 ℃; for 0.166667h;

DOI:10.1021/jo00027a037

Reference yield:

2-(trifluoromethyl)benzenamine (88-17-5) → N-<2-(Dimethylamino)ethyl>-2-phenylquinolin-4-amine (148726-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / 1.) -50 deg C, 2.) -78 deg C, 1h; -78 to 23 deg C, 1 h; 23 deg C, 2 h

2: 2 h / Heating

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/jo00099a014

Reference yield:

acetophenone (98-86-2) → N-<2-(Dimethylamino)ethyl>-2-phenylquinolin-4-amine (148726-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / p-toluenesulfonic acid / toluene / 10 h / Heating

2: 1.) n-butyllithium / 1.) ether, -10 deg C, 20 min, 2.) -5 deg C, 45 min

With n-butyllithium; toluene-4-sulfonic acid; In toluene;

DOI:10.1021/jm00109a031

upstream raw materials:

2-trifluoromethyl-N-(1-phenylethylidene)benzenamine

lithium N-<2-(dimethylamino)ethyl>amide

N-(1-phenylethylidene)-2-(trifluoromethyl)aniline

N,N-dimethylethylenediamine