6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine

Base Information

Chemical Name:6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine
CAS No.:1275595-87-3
Molecular Formula:C₂₉H₂₆ClFN₄O₂S
Molecular Weight:549.068
Hs Code.:

Synonyms:6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine

Suppliers and Price of 6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine

There total 4 articles about 6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 6950-53-4
2‐(methylsulfanyl)ethan‐1‐amine hydrochloride

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: 1275595-87-3
6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine

Guidance literature:: 2‐(methylsulfanyl)ethan‐1‐amine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde; With triethylamine; In methanol; dichloromethane; at 20 ℃;

With methanol; sodium tetrahydroborate; In dichloromethane; Cooling with ice;

Reference yield:

: C₂₉H₂₄ClFN₄O₂S

: 1275595-87-3
6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine

Guidance literature:: With sodium triacetoxyborohydride; In ethanol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.09.032

Reference yield:

: 27329-70-0
5-formylfurane-2-boronic acid

: 1275595-87-3
6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / ethanol / 2.5 h / 20 °C / Inert atmosphere; Reflux

2: sodium triacetoxyborohydride / ethanol / 2 h / 20 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium triacetoxyborohydride; triethylamine; In ethanol;
DOI:10.1016/j.ejmech.2013.09.032