{2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

Base Information

Chemical Name:{2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid
CAS No.:1415043-06-9
Molecular Formula:C₂₃H₂₂N₂O₅S
Molecular Weight:438.504
Hs Code.:

Synonyms:{2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

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Chemical Property of {2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

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Technology Process of {2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

There total 15 articles about {2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1415043-05-8
Ethyl 2-(2-methyl-4-oxo-3-(2-(phenylsulfonyl)benzyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate

: 1415043-06-9
{2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

Guidance literature:: Ethyl 2-(2-methyl-4-oxo-3-(2-(phenylsulfonyl)benzyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 0.25h;

With hydrogenchloride; In water; ethyl acetate; Product distribution / selectivity;

Reference yield: 26.0%

: 1415042-82-8
tert-butyl 1-(2-ethoxy-2-oxoethyl)-2-methyl-4-oxo-1,4,6,7-tetrahydro-5H-pyrrolo[3,2-c]pyridine-5-carboxylate

: 126076-76-4
2-(phenylsulfonyl)benzaldehyde

: 1415043-06-9
{2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

Guidance literature:: With water; hydrogen iodide; hypophosphorous acid; acetic anhydride; at 20 ℃; for 21h; Product distribution / selectivity;

Reference yield:

: 446-52-6
2-Fluorobenzaldehyde

: 1415043-06-9
{2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 4 h / 100 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

3: acetic anhydride; hypophosphorous acid; water; hydrogen iodide / 21 h / 20 °C

With water; hydrogen iodide; hypophosphorous acid; acetic anhydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; dimethyl sulfoxide;