1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-ol

Base Information

• Chemical Name: 1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-ol
• CAS No.: 128991-82-2
• Molecular Formula: C₁₄H₉ClFN₃O
• Molecular Weight: 289.696
• Mol file: 128991-82-2.mol

Synonyms:1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-ol

Chemical Property of 1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-ol

There total 1 articles about 1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorobenzoyl chloride (403-43-0) + 1-(4-chloro-phenyl)-semicarbazide (14580-27-9) → 1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-ol (128991-82-2)

Guidance literature:

With pyridine; potassium hydroxide; Yield given. Multistep reaction; 1) benzene, 3h, heating, 2) ethanol, 60 deg C, 1h;

DOI:10.1002/ardp.19903230408

Reference yield: 90.0%

1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-ol (128991-82-2) + benzoyl chloride (98-88-4) → Benzoic acid 1-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl ester (128992-05-2)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; for 10h; Heating;

DOI:10.1002/ardp.19903230408

Reference yield: 70.0%

4-(3-chloropropyl)morpholine (7357-67-7) + 1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-ol (128991-82-2) → 4-{3-[1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-yloxy]-propyl}-morpholine (128991-94-6)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; for 8h; Heating;

DOI:10.1002/ardp.19903230408

upstream raw materials:

4-fluorobenzoyl chloride

1-(4-chloro-phenyl)-semicarbazide

Downstream raw materials:

4-{3-[1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-yloxy]-propyl}-morpholine

1-{3-[1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-yloxy]-propyl}-4-methyl-piperazine; hydrochloride

Benzoic acid 1-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl ester