1-(2,4-dibromo-5-(2-fluoro-4-nitrophenoxy)benzylidene)-2-methylhydrazine

Base Information

Chemical Name:1-(2,4-dibromo-5-(2-fluoro-4-nitrophenoxy)benzylidene)-2-methylhydrazine
CAS No.:1206800-26-1
Molecular Formula:C₁₄H₁₀Br₂FN₃O₃
Molecular Weight:447.058
Hs Code.:

Synonyms:1-(2,4-dibromo-5-(2-fluoro-4-nitrophenoxy)benzylidene)-2-methylhydrazine

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Chemical Property of 1-(2,4-dibromo-5-(2-fluoro-4-nitrophenoxy)benzylidene)-2-methylhydrazine

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Technology Process of 1-(2,4-dibromo-5-(2-fluoro-4-nitrophenoxy)benzylidene)-2-methylhydrazine

There total 1 articles about 1-(2,4-dibromo-5-(2-fluoro-4-nitrophenoxy)benzylidene)-2-methylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.7%

: 1206800-25-0
2,4-dibromo-5-(2-fluoro-4-nitrophenoxy) benzaldehyde

: 60-34-4
methylhydrazine

: 1206800-26-1
1-(2,4-dibromo-5-(2-fluoro-4-nitrophenoxy)benzylidene)-2-methylhydrazine

Guidance literature:: In tetrahydrofuran; for 2h; Reflux;

Reference yield: 79.0%

: 1206800-26-1
1-(2,4-dibromo-5-(2-fluoro-4-nitrophenoxy)benzylidene)-2-methylhydrazine

: 1206800-24-9
6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole

Guidance literature:: With potassium carbonate; copper(l) chloride; In N,N-dimethyl-formamide; at 100 ℃; for 6.5h; Inert atmosphere;

Reference yield:

: 1206800-26-1
1-(2,4-dibromo-5-(2-fluoro-4-nitrophenoxy)benzylidene)-2-methylhydrazine

: 1206799-15-6
N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; copper(l) chloride / 6 h / 100 °C

2: potassium phosphate monohydrate; di-tert-butyl dicarbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 20 h / 20 - 40 °C / Large scale

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 45 h / 2585.81 Torr / Large scale

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 9 h / Reflux; Large scale

With potassium phosphate monohydrate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); di-tert-butyl dicarbonate; palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; copper(l) chloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1021/op400317z