1-methyl-3-oxo-indazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane

Base Information

• Chemical Name: 1-methyl-3-oxo-indazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane
• CAS No.: 103748-74-9
• Molecular Formula: C₂₉H₂₅N₂O₃P
• Molecular Weight: 480.503
• Mol file: 103748-74-9.mol

Synonyms:1-methyl-3-oxo-indazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane

Chemical Property of 1-methyl-3-oxo-indazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-3-oxo-indazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane

There total 1 articles about 1-methyl-3-oxo-indazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-oxoindazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane (86660-66-4) + methyl iodide (74-88-4) → 1-methyl-3-oxo-indazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane (103748-74-9)

Guidance literature:

With potassium carbonate; In methanol; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96683-9

Reference yield:

1-methyl-3-oxo-indazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane (103748-74-9) → 1-Methyl-4-oxo-1,4-dihydro-quinazoline-2-carboxylic acid methyl ester (103748-79-4) + triphenylphosphine (603-35-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 45 ℃; for 2h; Yield given;

DOI:10.1016/S0040-4020(01)96683-9

Reference yield:

1-methyl-3-oxo-indazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane (103748-74-9) → 2-formyl-phenylazo(phenylsulphonyl)methylenetriphenylphosphorane (103748-71-6,103763-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: p.toluenesulfonic acid / toluene / 2 h / 45 °C

2: Et₃N / acetonitrile / Ambient temperature

With toluene-4-sulfonic acid; triethylamine; In toluene; acetonitrile;

DOI:10.1016/S0040-4020(01)96683-9

upstream raw materials:

3-oxoindazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane

methyl iodide

Downstream raw materials:

1-Methyl-4-oxo-1,4-dihydro-quinazoline-2-carboxylic acid methyl ester

triphenylphosphine

2-formyl-phenylazo(phenylsulphonyl)methylenetriphenylphosphorane

2-formyl-4,5-methylenedioxy-phenylazo(methoxycarbonyl)methylenetriphenylphosphorane